–  Hydrodynamic size: diameter is 180 nm
–  Fe content: ~106 Fe atoms per particle
–  Integrin targeting: 3 500 RGD per particles
–  Recommended dose: 200 μmolFe/kg = 2.5 μL/g
Example: for a 30g body weight mouse, injection volume is 75 μL
–  Recommended imaging time: up to 1h post injection (unbound contrast agent cleared from the blood)
–  Contrast mechanism: susceptibility effect
–  Histology: Perl’s staining
–  In vitro quantification techniques: P04000 is a Fe-based contrast agent. Thus, it is necessary to take into account the endogenous iron content for quantification in biological media by ICP-AES or ICP-MS. Another way for USPIO quantification is relaxometry, which is poorly sensitive to endogenous iron content.

–  Concentration: [Fe] = 4.47 mgFe/mL – [Fe] = 80 mmol/L (MFe=56 g/mol)

–  Volume: 450 μL (5 mice dose approx.)

–  Other animal species: contact us